Welcome to our lab's website !
Aging and age-related diseases are central to human health and longevity. We study the molecular mechanisms that regulate aging and hope to exploit them for therapeutic purposes. For more details on our research, please follow this link.
We are located at the new Integrated Cardio Metabolic Center (ICMC) at Karolinska Institute (KI) in Stockholm/Sweden. ICMC is a joint research center between KI and the pharmaceutical company AstraZeneca, aiming to develop innovative treatments for human diseases.
What's new?
new publication
06.10.20 - We just published a new manuscript - a protocol that we hope will be useful for the C. elegans community: "Histone purification combined with high-resolution mass spectrometry to examine histone posttranslational modifications and histone variants in Caenorhabditis elegans". The protocols is available at Current Protocols in Protein Science and can be accessed here.
two open postdoc positions!
16.09.20 - We are recruiting two postdocs for the following projects:
1) "Molecular mechanisms that regulate aging"; see here for the ad.
2) "Identification of aging-preventive interventions by a transcriptomics-based screening approach"; see here for the ad.
new publication
16.01.20 - I am happy to share with you our latest publication "DAF-16/FOXO requires Protein Phosphatase 4 to initiate transcription of stress resistance and longevity promoting genes", which came out a few days ago in Nature Communications. The paper can be accessed here.
project grant from Vetenskapsrådet (the Swedish Research Council) awarded
06.11.19 - We just received a new project grant from the Swedish Research Council (Vetenskapsrådet), to continue our work on DAF-16/FOXO-related mechanisms that influence how fast we age.
new publication
10.04.19 - We are excited about a new research paper from our lab entitled "Transcriptomics-Based Screening Identifies Pharmacological Inhibition of Hsp90 as a Means to Defer Aging" in Cell Reports. The paper can be accessed here.
new publication
24.10.18 - Our lab just published a new research paper entitled "DAF-16/FOXO and HLH-30/TFEB function as combinatorial transcription factors to promote stress resistance and longevity" in Nature Communications. The paper can be accessed here.
new publication
10.10.18 - Xin, Ilke, and Christian just published a review entitled "Regulation of Age-related Decline by Transcription Factors and Their Crosstalk with the Epigenome" in Current Genomics. The review can be accessed here.