the Riedel Laboratory

discovering and targeting the mechanisms that regulate age-reated decline


  • Millan-Arino, L., Yuan, Z.F., Oomen, M.E., Brandenburg, S., Chernobrovkin, A., Salignon, J., Körner, L., Zubarev, R.A., Garcia, B.A., Riedel, C.G. (2020) Histone purification combined with high-resolution mass spectrometry to examine histone posttranslational modifications and histone variants in Caenorhabditis elegans. Current Protocols in Protein Science 102(1): e114. Pubmed
  • Sen, I., Chernobrovkin, A., Puerta Cavanzo, N., Liu, M., Lin, X.X., Baskaner, B., Brandenburg, S., Zubarev, R.A., Riedel, C.G. (2020) DAF-16/FOXO requires Protein Phosphatase 4 to initiate the transcription of stress resistance and longevity promoting genes. Nature Communications 11(1): 138. Pubmed
  • Janssens, G.E., Lin, X.X., Millan-Arino, L., Sen, I., Kavsek, A., Seinstra, R.I., Stroustrup, N., Nollen, E.A.A., Riedel, C.G. (2019) Transcriptomics-based screening identifies pharmacological inhibition of Hsp90 as a means to defer aging. Cell Reports 27: 467-480.  Pubmed
  • Lin, X.X., Sen, I., Janssens, G.E., Zhou, X., Fonslow, B.R., Edgar, D., Stroustrup, N., Swoboda, P., Yates 3rd, J.R., Ruvkun, G., Riedel, C.G. (2018) DAF-16/FOXO and HLH-30/TFEB function as combinatorial transcription factors to promote stress resistance and longevity. Nature Communications 9(1): 4400.  Pubmed
  • Zhou, X., Sen, I., Lin, X.X, Riedel, C.G. (2018) Regulation of age-related decline by transcription factors and their crosstalk with the epigenome. Current Genomics, 19(6): 464-482.  Pubmed
  • Lezzerini, M., Riedel, C.G. (2016) ATP-dependent chromatin remodeling: from development to disease. Book Chapter in “Chromatin Regulation and Dynamics”, Elsevier, ISBN: 978-0-12-803395-1.  ScienceDirect
  •  Heimbucher, T., Liu, Z., Bossard, C., McCloskey, R., Carrano, A., Riedel, C.G., Tanasa, B., Klammt, C., Fonslow, B.R., Riera, C., Lillemeier, B.F., Kemphues, K., Yates, J.R. 3rd, O'Shea, C., Hunter, T., Dillin, A. (2015) The deubiquitylase MATH-33 controls DAF-16 stability and function in metabolism and longevity. Cell Metabolism 22(1):151-63.0.  Pubmed
  •  Riedel, C.G., Dowen, R.H., Lourenco, G.F., Kirienko, N.V., Heimbucher, T., West, J.A., Bowman, S.K., Kingston, R.E., Dillin, A., Asara, J.M., Ruvkun, G. (2013). DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity. Nature Cell Biology, 15, 491-501.  Pubmed
  • Zhang, C., Montgomery, T.A., Fischer, S.E., Garcia, S.M., Riedel, C.G., Fahlgren, N., Sullivan, C.M., Carrington, J.C., Ruvkun, G. (2012). The Caenorhabditis elegans RDE-10/RDE-11 Complex Regulates RNAi by Promoting Secondary siRNA Amplification. Current Biology, 22, 881-90.  Pubmed
  • Hayes, G., Riedel, C.G., Ruvkun, G. (2011). The Caenorhabditis elegans SOMI-1 zinc finger protein and SWI/SNF promote regulation of development by the mir-84 microRNA. Genes & Development 25, 2079-2092.  Pubmed
  • Rizki, G., Iwata, T.N., Li, J., Riedel, C.G., Picard, C.L., Jan, M., Murphy, C.T., and Lee, S.S. (2011). The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO. PLoS Genetics 7, e1002235.  Pubmed
  • Riedel, C.G. (2010). Toward the mechanisms preventing merotelic kinetochore-microtubule attachments. Cell Cycle 9.  Pubmed
  • Rumpf, C., Cipak, L., Dudas, A., Benko, Z., Pozgajova, M., Riedel, C.G., Ammerer, G., Mechtler, K., and Gregan, J. (2010). Casein kinase 1 is required for efficient removal of Rec8 during meiosis I. Cell Cycle 9, 2657 - 2662.  Pubmed
  • Curran, S.P., Wu, X., Riedel, C.G., and Ruvkun, G. (2009). A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants. Nature 459, 1079-84.  Pubmed
  • Gregan, J.*, Riedel, C.G.*, Pidoux, A.L.*, Katou, Y., Rumpf, C., Schleiffer, A., Kearsey, S.E., Shirahige, K., Allshire, R.C., Nasmyth, K. (2007). The kinetochore proteins Pcs1 and Mde4 and heterochromatin are required to prevent merotelic orientation. Current Biology 17, 1190-200.   *:equal contribution.  Pubmed
  • Gregan, J., Riedel, C.G., Petronczki, M., Cipak, L., Rumpf, C., Poser, I., Buchholz, F., Mechtler, K., and Nasmyth, K. (2007). Tandem affinity purification of functional TAP-tagged proteins from human cells. Nature Protocols 2, 1145-51.  Pubmed
  • Riedel, C.G.*, Katis, V.L.*, Katou, Y., Mori, S., Itoh, T., Helmhart, W., Gálová, M., Petronczki, M., Gregan, J., Cetin, B., Mudrak, I., Ogris, E., Mechtler, K., Pelletier, L., Buchholz, F., Shirahige, K., and Nasmyth, K. (2006). Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I. Nature 441, 53-61.   *:equal contribution.  Pubmed
  • Riedel, C.G.*, Mazza, M.*, Maier, P., Körner, R., and Knop, M. (2005). Differential requirement for phospholipase D/Spo14 and its novel interactor Sma1 for regulation of exocytotic vesicle fusion in yeast meiosis. Journal of Biological Chemistry 280, 37846-52.   *:equal contribution.  Pubmed
  • Riedel, C.G.*, Gregan, J.*, Gruber, S., and Nasmyth, K. (2004). Is chromatin remodeling required to build sister-chromatid cohesion? Trends in Biochemical Sciences 29, 389-92.   *:equal contribution.  Pubmed
  • Knop, M., Barr, F., Riedel, C.G., Heckel, T., and Reichel, C. (2002). Improved version of the red fluorescent protein (drFP583/DsRed/RFP). BioTechniques 33, 592, 594, 596-8 passim.  Pubmed

This site has been built using Joomla und uses cookies as well as Google Analytics. By visiting our website you allow us, to use cookies and to pass on data to third parties (in particular Google Analytics).